Alcohol and Opiates. Neurochemical and Behavioral Mechanisms by Kenneth Blum

By Kenneth Blum

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And LeBlanc, A. : Effect of acute and chronic ethanol administration on serotonin turnover in rat brain. Psychopharmacologia 37: 91-100 (1974). , Svensson, T. H. : Effect of ethanol on the metabolism of brain catecholamines. Psychopharmacologia 30:27-36 (1973). Hunt, W. A. : Effects of ethanol on serotonin turnover. Brain Res. 22:181-184 (1974). Patel, G. J. : Reduction in brain γ-aminobutyric acid and in bartibal narcosis during ethanol withdrawal. J. Pharm. Exp. Ther. 186:625-629 (1973). Rawat, A.

Effects on Action Potential Generation In all Aplysia neurons investigated, ethanol (2 to 5%) produced reductions in spike amplitude of 20 to 50% (Figure 2 and references 4 and 12). This effect was mainly due to a decreased rate of rise of the action potential. Since the inward current underlying spike initiation in molluscan neurons is carried by both Na + and Ca"1"*", (29,30) we tested the possibility that both conductance mechanisms are altered by ethanol. This was the case; ethanol reduces the size of action potentials remaining in either sodium-free or calcium deficient ASW.

MECHANISMS BY WHICH ETHANOL MAY ALTER NE TURNOVER—ROLE TIQ ALKALOIDS OF ETHANOL DEPENDENCE 29 There are, however, several other phenomena which may occur during the chronic intake of ethanol and contribute to the observed increase in NE turnover. One of the widely debated (48,49) possibilities is the formation of tetrahydroisoquinoline alkaloids (TIQ's) in the CNS during ethanol intoxication. These alkaloids have been demonstrated to arise from the spontaneous condensation of either acetaldehyde (eg.

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