An Introduction to Mechanisms in Pharmacology and by Howard Rogers and Roy G. Spector (Auth.)

By Howard Rogers and Roy G. Spector (Auth.)

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1966) The mathematics of drug-receptor interactions /. Pharm. Pharmac, 18, 201 - 222. , Molinoff P. and Potter T. L. (1971) Isolation of cholinergic receptor protein of Torpedo electric tissue Nature 2 2 9 , 5 5 4 - 557. Molecular Properties of Drug Receptors - Ciba Foundation Symposium (1970) Eds. R. Porter and M. O'Connor, J. and A. Churchill. , Wyman J. and Changeux J - P (1965) On the nature of allosteric transitions: a plausible model J. Mol. Biol. 12, 88 - 118. O'Brien R. , Eldefrawi M.

R. (1968) Pharmacological Receptors Pharmac. Rev. 2 0 , 49 - 88. 3 Cell Membranes Electron micrographs of cells generally show that they are bound by a trilaminar membrane. 5nm and consists of a single light band sandwiched between two dark bands. Chemical analysis shows that membranes contain both protein and lipid. There is evidence that the outer dark stripes consist predominantly of protein and the inner light band is mainly a hydrophobic region containing the non polar tails of lipids and non polar regions of proteins.

In the dark stripes) the polar portions of lipids are associated with polar groups of the membrane proteins by electrostatic forces. The components within the middle layer are presumably bound by hydrophobic forces. Incorporated into this basic simple structure are several other features: (a) There are variations in membrane thickness which in some areas may be associated with an absence of lipid and the total membrane thickness is occupied by protein, (b) Another variation in chemical composition is the presence of carbohydrate over the surface of the external outer protein layer.

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